Replication of a Novel Parkinson's Locus in a European Ancestry Population

Background A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17. Objectives The objective this were to determine whether WBSCR17 loci contribute the developing PD in European ancestry populations. Methods We report an analysis variants with COURAGE-PD cohort (9673 patients; 8465 controls) comprising individuals ancestries. In addition, publicly available summary data (41,386 476,428 pooled. Results Our findings confirmed role variant pathogenesis (rs246814, PEuropean = 6.64 × 10?4, pooled P 1.15 10?11). rs9638616 was observed as a significant marker population only (P 1.16 10?8). Conclusions comprehensive provides up-to-date detected different populations locus factor for irrespective or ethnic group analyzed. © 2021 Authors. Movement Disorders by Wiley Periodicals LLC on behalf International Parkinson Disorder Society